Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects

Rabeb Tej,Najoua Karray Bouraoui,Mokhtar Lachaal,Samia Oueslati,Riadh Ksouri,Amel Hamdi,Moufida Saidani Tounsi,Raja Serairi Beji,Iness Bettaieb Rebey,Wissem Aidi Wannes

doi:10.1590/s2175-97902019000118064

Abstract

The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment.

Highlights

Diabetes mellitus (DM) is a chronic endocrine metabolic disorder that poses a major public health problem around the world
Based on the absorbance values of the various extract solutions compared with the standard solution of gallic acid and catechin, total phenolic and flavonoid amounts were equal to 9.31±0.02 mg GAE/g DW and 6.01±17 mg CE/g DW, respectively (Table I)
The alloxaninduced diabetic rats exhibited a significant loss of the body weight as compared with control

Summary

Introduction

Diabetes mellitus (DM) is a chronic endocrine metabolic disorder that poses a major public health problem around the world. The World Health Organization (WHO) predicted it would be the 7th leading cause of death by 2030 (WHO, 2011). Diabetes frequently leads to serious complications (Deshpande, Harris-Hayes, Schootman, 2008), namely nephropathy, neuropathy and retinopathy (Winkler et al, 2010), which can be delayed and reduced by maintaining tight glycemic control. Glucose homeostasis disorders involve abnormalities in lipid metabolism characterized by a reduced cholesterol rate in high-density lipoprotein and increased triglyceride, total cholesterol and cholesterol rates of low-density lipoprotein (Capewell et al, 2010). Hyperlipidemia poses a major risk for the premature development of atherosclerosis and cardiovascular complications (Goldstein et al, 1973)

Objectives

Methods

Results

Discussion

Conclusion