Abstract
Jones studied the luteal phase by evaluating basal body temperature charts, urinary pregnanediol excretion (48-hour urine collection at the peak of luteal phase by basal body temperature), cervical mucus, and most importantly, timed endometrial biopsies. In the initial study, Jones evaluated 255 cycles in 98 women with infertility that was not due to tubal, uterine, anovulation or male factor.
Highlights
Luteal Phase Deficiency (LPD), known as luteal phase defect, is a concept that was defined by Georgeanna Seegar Jones in 1949 as reduced progesterone production by the Corpus Luteum (CL) [1]
LPD results from low endogenous progesterone production and the resultant insufficiency to maintain a secretory endometrium to allow embryo implantation and growth [2]
Basal Body Temperature (BBT) rise occurs when progesterone increases during the mid-luteal cycle, roughly a temperature elevation of 1° F for every approximate rise of 2.5 ng/mL of progesterone [17]. While this method is thought to have a high sensitivity for detecting ovulation, it does not accurately correlate with endometrial histology [17], and up to 22.1% of women with hormonally normal menstrual cycles may experience an abnormal BBT [18]
Summary
Luteal Phase Deficiency (LPD), known as luteal phase defect, is a concept that was defined by Georgeanna Seegar Jones in 1949 as reduced progesterone production by the Corpus Luteum (CL) [1]. Jones studied the luteal phase by evaluating basal body temperature charts, urinary pregnanediol excretion (48-hour urine collection at the peak of luteal phase by basal body temperature), cervical mucus, and most importantly, timed endometrial biopsies. By assessing the delayed dating of the luteal phase endometrium, she determined that at least 50 percent of these women had either inadequate luteal stimulation or defective endometrial response, indicating many women could be suffering from this condition [3]. Luteal phase deficiency has been a controversial subject, with many doubting its existence and its association with infertility. The goal of this article is to review the historical and current understanding of LPD and its association with infertility
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
