Abstract
Twelve healthy volunteers were studied to observe the effect of intravenous (iv) lidocaine on hemostatic and platelet function. Prothrombin time (PT), accelerated partial thrombin plastein time (aPTT) and thromboelastography (TEG) were measured before and after iv infusion of lidocaine at a dose of 5 mg/kg over 30 minutes. In contrast to previous studies, no significant changes were observed in all measured variables of hemostasias. In one case the plasma lidocaine level was above the therapeutic range, yet all hemostatic parameters were within the normal range.
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