Abstract
Does leucocyte concentration have a role in the outcome of PRP therapy for lateral epicondylitis – A randomized controlled trial - IJOR- Print ISSN No: - 2581-8112 Online ISSN No:- 2581-9151 Article DOI No:- 10.18231/j.ijor.2020.020, IP International Journal of Orthopaedic Rheumatology-IP Int J Orthop Rheumatol
Highlights
Regenerative medicine has paved the way for less invasive techniques, minimal morbidity, and percutaneous administration of biological substances with osteoinductive and osteoconductive properties. 1 Platelet-rich plasma (PRP) injection has evolved as a big boon in the treatment of musculoskeletal disorders
We aimed to evaluate the effects of leucocyte concentration in the outcomes of the platelet-rich plasma (PRP) used for lateral epicondylitis
A total of 85 patients were randomized into leucocyte-poor PRP (LP-PRP) (n=42) and leucocyte-rich PRP (LR-PRP) (n=43) with a mean age of 49.67 (SD=11.9) and M:F = 1.34
Summary
Regenerative medicine has paved the way for less invasive techniques, minimal morbidity, and percutaneous administration of biological substances with osteoinductive and osteoconductive properties. 1 Platelet-rich plasma (PRP) injection has evolved as a big boon in the treatment of musculoskeletal disorders. Leucocyterich PRP (LR-PRP) elicits a catabolic, inflammatory, and detrimental environment while Leucocyte-poor PRP (LP-PRP) elicits an anabolic effect on the tissues being injected. 9. Of late the leucocyte concentration in the platelet-rich plasma (PRP) therapy for lateral epicondylitis has gained importance. Materials and Methods: This is a double-blinded randomized controlled trial conducted on patients having lateral epicondylitis comparing the pain relief and functional effects of leucocyte-poor PRP (LP-PRP) and leucocyte-rich PRP (LR-PRP) at one, three, six, and twelve months post-injection using the Visual Analog Scale (VAS) for pain and Mayo Elbow Performance Score (MEPS) for function. Conclusion: PRP injections are a safe and effective treatment method in the management of patients with lateral epicondylitis irrespective of the concentration of the leucocytes present in them. We have established that the concentration of leucocytes did not play a role in altering the course of the treatment outcome
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
