Abstract
Obesity in pregnancy is becoming increasingly common and is associated with many pregnancy-related complications such as failed induction of labor (IOL). Leptin, an adipocytokine important in energy homeostasis, is found in higher levels in obese individuals. Leptin has also been demonstrated to have an inhibitory effect on myometrial contractility in vitro. We hypothesize that leptin may play a part in the mechanism of dysfunctional labor. Thus, we sought to compare the maternal plasma leptin levels in women that had a successful vaginal delivery post-IOL vs. those who had a C-section post-IOL.
Highlights
H many pregnancy-related complications such as failed induction of labor (IOL)
A total of 168 women underwent induction of labor, with 54 delivering via Cesarean section compared to 114 women who had successful lOL and delivered vaginally
Information on maternal/neonatal characteristics was collected from the Maternal-Fetal Tissue Bank (MFTB) secure database and verified in the electronic medical record
Summary
Obesity in pregnancy is becoming increasingly common and is associated with many pregnancy-related complications such as failed induction of labor (IOL). An adipocytokine important in energy homeostasis, is found in higher levels in obese individuals. Leptin has been demonstrated to have an inhibitory effect on myometrial contractility in vitro. We hypothesize that leptin may play a part in the mechanism of dysfunctional labor. We sought to compare the maternal plasma leptin levels in women that had a successful vaginal delivery post-IOL vs those who had a C-section post-IOL
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
