Abstract
1. The liver and serum of rats was studied 18 hr following the i.p. administration of 0.5mg Pb 2+/100 g body wt. 2. The incorporation of [ 14C]leucine into proteins was measured in ribosomal and mRNA fractions incubated in vitro and was markedly stimulated in the Pb 2+ treated rats. 3. Similar results were found when the proteins of liver and serum were labelled by the injection in vivo of [ 14C]leucine. 4. The increased mRNA activity appears to be chiefly for acid serum proteins of approx. M r , 44,000, 41,000, 33,000 and 18,000.
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