Abstract
Depression in older adults occurs in the context of biological aging that contributes to the clinical symptoms, biomarkers, and the course of the disease1. Neurobiology of aging and late life mental disorders share features of increased cellular senescence, inflammation, and reduced mitochondrial function. In addition, serious mental disorders (SMDs), including major depression, are associated with an increased risk of medical illnesses and premature mortality from natural causes, with lifespans up to 25 years shorter than the general population, even after controlling for suicide1.
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