Abstract
Does inhibition of apolipoprotein B synthesis produce foie gras?
Highlights
The development of statin drugs has revolutionized the treatment of hyperlipidemia and cardiovascular disease
A genetic disorder frequently due to mutations in the apolipoprotein B gene resulting in truncated forms of apolipoprotein B-100, characteristically exhibit very low LDL cholesterol levels and appear to be protected from cardiovascular disease [9]
Treatment with microsomal triglyceride transfer protein inhibitors, which block the transfer of triglyceride to apolipoprotein B-100 and thereby decrease VLDL formation and secretion, results in a marked increase in hepatic triglyceride storage [12]
Summary
The development of statin drugs has revolutionized the treatment of hyperlipidemia and cardiovascular disease. Studies have shown that mipomersen treatment results in a reduction in serum cholesterol levels [5, 6]. In this issue of the Journal of Lipid Research, Visser et al [7] show that adding mipomersen (200 mg given subcutaneously weekly) to statin therapy results in a further reduction in LDLc (−22%), non-HDLc (−21%), Lp(a) (−19.6%), and apolipoprotein
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