Abstract
In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-γ) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin prick test and specific IgE against common aeroallergens. Atopic status was associated with eosinophilia and production of Th2 type cytokines. Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with IFN-γ and elevated monocytes in blood. IFN-γ and monocytes might play a role in immunopathology of non-atopic asthma in Latin American children.
Highlights
In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma
The immunopathological features of atopic asthma are well characterized as an eosinophilic bronchitis in the airways, with the inflammatory process governed by Th2 cytokines, such as IL-4, IL-5 and IL-13, the immunological and cellular profiles of non-atopic asthma are not well known
Children were classified into 4 groups based on the detection of allergenspecific IgE in serum and asthma symptoms: atopic asthmatic, non-atopic asthmatic, atopic non-asthmatic and non-atopic non-asthmatic
Summary
In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). * Correspondence: mauricio@ufba.br 7Instituto de Saúde Coletiva, Universidade Federal de Bahia, Rua Basilio da Gama s/n, Canela, 41110-040, Salvador-Bahia, Brazil Full list of author information is available at the end of the article presented increased eosinophils and IFN-γ [6].
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