Abstract
This prospective randomised study enrolled 102 preterm infants with patent ductus arteriosus. The patent ductus arteriosus closure rate was significantly higher in the oral ibuprofen group (84.6 versus 62%) after the first course of treatment (p=0.011). No significant difference was found between the pre- and post-treatment total oxidant status and total antioxidant capacity in the groups. Discussion Ibuprofen treatment does not change the total oxidant status or total antioxidant capacity. We believe that the effect of ibuprofen treatment in inducing ischaemia overcomes the scavenging effect of ibuprofen.
Highlights
Ibuprofen is used widely to close patent ductus arteriosus in preterm infants
After the first course of treatment, the patent ductus arteriosus was closed in 46 (84.6%) of the patients assigned to the oral ibuprofen group versus 31 (62%) of those enrolled to the intravenous ibuprofen group (p = 0.011)
This study examined changes in total antioxidant capacity and total oxidant status after oral and intravenous ibuprofen treatments
Summary
Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen. Materials and methods: This study enrolled newborns of gestational age ⩽ 32 weeks, birth weight ⩽ 1500 g, and postnatal age 48–96 hours, who received either intravenous or oral ibuprofen to treat patent ductus arteriosus. Total oxidant status and total antioxidant capacity were measured using Erel’s method. The patent ductus arteriosus closure rate was significantly higher in the oral ibuprofen group (84.6 versus 62%) after the first course of treatment (p = 0.011). No significant difference was found between the preand post-treatment total oxidant status and total antioxidant capacity in the groups. Discussion: Ibuprofen treatment does not change the total oxidant status or total antioxidant capacity. We believe that the effect of ibuprofen treatment in inducing ischaemia overcomes the scavenging effect of ibuprofen
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