Abstract
The present analysis compares two palliative treatment concepts for lung cancer in terms of overall survival. Survival data from 207patients were used in a retrospective analysis. All patients received palliative treatment comprising either 25Gy applied in 5fractions or 50Gy in 20fractions. A subgroup analysis was performed to compare patients with a good-fair vs. poor overall condition. Median survival times were 21weeks (range6-26weeks) for patients treated with 25Gy in 5fractions and 23weeks (range14.5-31.5weeks) for patients treated with 50Gy in 20fractions (95 % confidence interval, CI; p = 0.334). For patients with a good-fair overall condition, median survival times were 30weeks (21.8-39.2weeks) for 25Gy in 5fractions and 28weeks (14.2-41.8weeks) for 50Gy in 20fractions (CI 95 %, p = 0.694). In patients with a poor overall condition, these values were 18weeks (14.5-21.5weeks) and 21weeks (13.0-29.0weeks), respectively (CI 95 %, p = 0.248). The palliative treatment concept of 25Gy applied in 5fractions is sufficient for radiation of lung cancer, given that there was no obvious survival improvement in patients treated with the higher total dose regimen.
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