Abstract
The heparin regimen providing anticoagulation during cardiopulmonary bypass (CPB) is usually adapted to total body weight (TBW). However, this may cause redundant anticoagulation and increase perioperative bleeding, transfusion requirements and reoperation. We compared a heparin regimen based on ideal body weight (IBW) with the traditional regimen. After ethical approval, 100 adults undergoing elective cardiac surgery with CPB were recruited for the prospective, observational study in a tertiary hospital. Prior to CBP an unfractioned heparin dose was adjusted to 300 IU/kg based on TBW (Group TBW, n=50), or IBW (Group IBW, n=50). IBW was calculated using the Lorentz formula. The minimal Activated Coagulation Time (ACT) target value is 400 sec for CPB. Demographic data, cross-clamp and CPB durations, and Hb, Htc, platelet, PT, Aptt and fibrinogen values were similar between the groups (p>0.05). Heparin and total protamine doses were significantly higher in Group IBW (p
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