Does Helicobacter pylori play a role in the pathogenesis of non-cystic fibrosis bronchiectasis?

Abstract

The aim of this study was to investigate whether Helicobacter pylori plays a role in the pathogenesis and severity of non-cystic fibrosis bronchiectasis, and its relationship with gastroesophageal reflux (GER). Forty-one patients and 16 controls between 5 and 18 years of age were enrolled. H.pylori was investigated on polymerase chain reaction and culture in gastric juice (GJ) and bronchoalveolar lavage fluid (BALF). Urea breath test (UBT) was also used for defining H.pylori infection. GER was detected on 24h pH monitoring or scintigraphy. Computed tomography (CT) scoring was used to quantify the severity and extent of bronchiectasis. Nine patients (22%) in the bronchiectasis group (BG) and three patients (18.8%) in the control group (CG) had H.pylori-positive BALF. Sixteen BG patients (39%) and seven CG patients (43.8%) had H.pylori-positive GJ. UBT was positive in 11 BG patients (26.8%) and in three CG patients (18.8%). H.pylori positivity in BALF, GJ and UBT was not significantly different between the two groups (P > 0.05). Six patients with GER and five patients without GER in BG had H.pylori-positive BALF and GJ (P = 0.827). No association was found between BALF H. pylori positivity and forced expiratory volume in 1 s (FEV1 ) in BG. CT score was significantly higher in BG patients with H.pylori-positive compared with H.pylori-negative BALF (P < 0.05). Helicobacter pylori is not associated with the pathogenesis of bronchiectasis but it may be responsible for the severity of the disease.