Abstract
Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported. We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing health examination. The total prevalence of HBsAg tested positive in cancer group was significantly higher than the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%, P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group (9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum marker negative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001). There may be a correlation between HBV infection and endometrial carcinoma.
Highlights
The connection between inflammation and cancer is generally accepted
In endometrial carcinoma (EC), several reports had demonstrated that tumor-associated macrophages (TAMs) in tumor microenvironment played an important role in the promotion of angiogenesis, progesterone receptor loss, and were correlated with worse prognosis (Mantovani et al, 2005; Jiang et al, 2012; Jiang et al, 2013)
The prevalence of HBV surface antigen (HBsAg) tested positive in the young age group was higher than the control group (28.6% vs 5.0%, P=0.001); the prevalences of HBsAg tested positive in the middle (40-59 years old) and old age (≥60) subgroups of endometrial cancer were higher than those corresponding subgroups of the control group (13.2% vs 8.1%, P=0.043; 8.6% vs 2.3%, P=0.027, respectively)
Summary
The connection between inflammation and cancer is generally accepted. In endometrial carcinoma (EC), several reports had demonstrated that tumor-associated macrophages (TAMs) in tumor microenvironment played an important role in the promotion of angiogenesis, progesterone receptor loss, and were correlated with worse prognosis (Mantovani et al, 2005; Jiang et al, 2012; Jiang et al, 2013). Experimental and epidemiological studies indicated a strong link between chronic inflammation and tumor progression. It was reported that HBV infection was associated with several type of cancers, such as hepatocellular carcinoma (Iavarone et al, 2013), non-Hodgkin lymphoma (Becker et al, 2012), pancreatic cancer (Jin et al, 2013), cervical cancer (Siu et al, 2007). Based on these studies, the status of HBV can not be ignored during the treatment of tumor diseases (King et al, 2010). We analyzed HBV serum marker status in the 398 patients of endometrial cancer, compared to 788 women from health examination
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
