Abstract

To determine how neonatal growth velocity affects the association between birth weight and neurodevelopmental outcomes in infants born preterm. This study is a secondary analysis of the Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia in Very Preterm Infants (MOBYDIck) randomized multicenter trial conducted in breastfed infants born at <29weeks of gestation, whose mothers were supplemented with docosahexaenoic acid or placebo during the neonatal period. Neurodevelopmental outcomes were assessed at 18-22months of corrected age using the Bayley-III cognitive and language composite scores. The role of neonatal growth velocity was assessed with causal mediation and linear regression models. Subgroup analyses were stratified by birth weight z-score categories (<25th, ≥25th-≤75th, and >75th percentiles). Neurodevelopmental outcomes were available for 379 children (mean gestational age, 26.7± 1.5 weeks). Growth velocity partially mediated the relationships between birth weight and cognitive (β=-1.1; 95% CI, -2.2 to -0.02; P=.05) and language scores (β=-2.1; 95% CI, -3.3 to -0.8; P=.002). An increase by 1g/kg/day in growth velocity was associated with an increase by 1.1 point in the cognitive score (95% CI, -0.03 to 2.1; P=.06) and 1.9 point in the language score (95% CI, 0.7 to 3.1; P=.001), after adjustment for birth weight z-score. For children with birth weight<25th percentile, a 1g/kg/day increase in growth velocity was associated with an increase by 3.3 points in the cognitive score (95% CI, 0.5 to 6.0; P=.02) and 4.1 points in the language score (95% CI, 1.3 to 7.0; P=.004). Postnatal growth velocity mediated the relationship between birth weight and neurodevelopmental performance, with larger effects for children with lower birth weight. Clinicaltrials.gov identifier: NCT02371460.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.