Does Gallbladder Wall Thickening of Cirrhotic Patients Increase the Risk of Formation of Gallstones?

Abstract

The objective of this study was to investigate whether gallbladder wall thickening in cirrhotic patients adds risk to the formation of gallstones. In this retrospective study, 259 patients with cirrhosis resulting from hepatitis B or hepatitis C were included (152 men, 107 women; mean ± SD, age 48.8 ± 11.4 years [range, 29–77 years]) and compared with 300 healthy participants comprising the control group. All participants had a standard abdominal sonographic assessment. The prevalence of gallstones in cirrhotic patients with and without gallbladder wall thickening was studied, and the distribution of gallstones and gallbladder wall thickening in different Child-Pugh classes was compared. The prevalence of gallstones in cirrhotic patients, cirrhotic patients with and without gallbladder wall thickening, and healthy participants was 27.4%, 28.8%, 13.0%, and 5.3%, respectively. The prevalence of gallstones in cirrhotic patients with gallbladder wall thickening was not significantly higher than in those without gallbladder wall thickening ( P > .05). Gallbladder wall thickening occurred with a higher frequency in Child-Pugh B and C patients, and normal thickness of the gallbladder wall was seen more frequently in Child-Pugh A patients ( P < .05). Gallstones were found more frequently in Child-Pugh A and C patients ( P < .05). In conclusion, gallbladder wall thickening in cirrhotic patients does not significantly add any risk for the formation of gallstones.