Abstract
Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded ∼20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2–10 μM) application, and inhibited by the 5-HT receptor blocker, ketanserin (50–100 μM). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms.
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