Abstract
Background/aimTo investigate the relationship between subfertility etiologies and success rates in controlled ovarian stimulation and intrauterine insemination (COS–IUI) cycles.Materials and methodsThe medical records of 218 couples who applied to a university-based fertility center were analyzed retrospectively. Detailed infertility examination data and pregnancy outcomes were compared according to different subfertility etiologies. The study groups with regard to subfertility etiologies were minimal–mild endometriosis, unexplained infertility, and mild male infertility. The primary outcome measure was live birth rate.ResultsThere were no statistically significant differences between the groups regarding demographics except for total motile sperm count. Live birth rates in the male infertility group were comparable to the endometriosis and unexpected infertility groups (6.6%, 11.9%, and 10.3%, respectively; P = 0.63).ConclusionThe success rate of the mild male subfertility group following COS–IUI cycles for live birth rates was similar to those of the endometriosis and unexplained subfertility groups.
Highlights
Subfertility is defined as the failure to conceive after 1 year of regular, unprotected intercourse
In this study, we compared live birth rates between subfertile couples with mild male infertility, minimal–mild endometriosis, and unexplained infertility, and observed that live birth rates were similar between the groups
Controlled ovarian stimulation and Intrauterine insemination (IUI) increases pregnancy rates in subfertile women regardless of infertility etiology; IUI without ovarian stimulation has no effect on live birth rates [18,19,20,21,22]
Summary
Subfertility is defined as the failure to conceive after 1 year of regular, unprotected intercourse. It affects approximately 8%–15% of couples [1]. Intrauterine insemination (IUI) is a procedure in which processed and concentrated motile sperm are placed directly into the uterine cavity with an insemination canula. Intrauterine insemination, with or without ovarian stimulation, is frequently used as a first line infertility treatment because it is a relatively inexpensive, less invasive, and effective method which is indicated for different subfertility etiologies [2,3,4]. The intrauterine insemination procedure can be applied with normal menstrual cycles or controlled ovarian stimulation (COS). Clomiphene citrate, letrozole, or gonadotropins can be used for COS. It is reported that the best pregnancy rate is achieved by COS–IUI using gonadotropins when compared to other treatments [6,7,8]
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