Abstract
IntroductionAtrial fibrillation (AF) is the most common sustained arrhythmia. Sorting nexin 10 (SNX10) has been reported to be an important regulator in embryonic development and human diseases, however, little is known about its role in cardiac disease. The aim of this study was to investigate the clinical significance of SNX10 expression in AF.MethodsNineteen valvular heart disease patients with AF and nine valvular heart disease patients with sinus rhythm (SR) were enrolled. Atrial tissue samples from patients undergoing open heart surgery were examined. Atrial tissues of normal hearts were obtained from two cases’ autopsies. The SNX10 expression and its associations with the degree of fibrosis were analyzed by immunohistochemistry and Masson’s trichrome staining.ResultsSNX10 expression was detected in the cytoplasm of cardiac cells in human myocardial tissue. The SNX10 expression level was higher in the SR group than in the AF group (P=0.023). SNX10 expression was negatively associated with the degree of fibrosis (P=0.017, Spearman rho=-0.447), the New York Heart Association degree (P=0.003, Spearman rho=-0.545), left atrial diameter (P=0.038, Spearman rho=-0.393), right atrial diameter (P=0.043, Spearman rho=-0.386), and the brain natriuretic peptide (BNP) level 24 hours after surgery (P=0.030, Spearman rho=-0.426), but not the BNP level before surgery and 72 hours after surgery. No statistical significance was observed between SNX10 and the level of troponin T and C-reactive protein.ConclusionDecreased SNX10 might serve as a potential risk factor in AF of the valvular heart disease.
Highlights
Atrial fibrillation (AF) is the most common sustained arrhythmia
Strong staining for Sorting nexin 10 (SNX10) was detected in the normal human tissue, and lower expression was observed in the myocardial tissue from the patients with valvular heart disease (Figure 1A)
The expression level of SNX10 was higher in the sinus rhythm (SR) group than in the AF group (Figure 1B, P=0.023), and was negatively associated with the degree of fibrosis (Figure 1C, P=0.017, Spearman rho=0.447, a moderate correlation), suggesting that decreased SNX10 is involved in AF
Summary
Atrial fibrillation (AF) is the most common sustained arrhythmia. The aim of this study was to investigate the clinical significance of SNX10 expression in AF. Atrial fibrillation (AF) is the most common cardiac arrhythmia and the cause of considerable morbidity, mortality, and healthrelated expenditures[1]. One of the clinical risk factors for the development of AF is valvular heart disease, which can cause structural atrial changes, including dilatation and fibrosis[2,3,4,5]. Structural changes underlying the atrial substrate, including atrial fibrosis and atrial dilatation, greatly contribute to permanent AF. Atrial fibrosis can change a homogeneously activated syncytial atrium into a discontinuous and branching structure susceptible for multiple wavelet re-entry[6].
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