Abstract
This study evaluates the platelet count changes in neonates with hyperbillirubinemia who received phototherapy. In this Prospective Descriptive-cross sectional study 144 full term newborns with indirect hyperbillirubinemia who received phototherapy in neonatal ward of Bessat hospital in Hamedan province of Iran were studied from September 2007 to February 2008 for evaluation the effect of phototherapy on platelet count. The platelet had counted by cell counter and it had controlled by slide platelet counting. The data were analyzed using spss version. 13 and compared with paired-samples T test. 58 neonates (40.3%) were boys and 86 (59.7%) were girls. The mean age of neonates was 7.04 +/– 5.49 days (2 - 29 days). The mean (± SD) platelet counts were 287833.3 + 92332.4 before and 299444.4 + 98565.2 after phototherapy. Analysis of data with paired T test showed significant difference in platelet count before and after phototherapy. Mean platelet count after phototherapy was higher than that before treatment. The study had propounded that mean platelet count increased with extended mean phototherapy time. This study had propounded this hypothesis that phototherapy in full term icteric newborns leads to increased platelet count. It may be due to accelerated platelet turnover in peripheral microvasculature with adequate platelet reserve.
Highlights
Phototherapy is the most widely used therapeutic modality in infants with neonatal jaundice
According to limited studies with controversial results, the aim of this research was evaluating the hypothesis that conventional phototherapy is able to change platelet count in neonates with indirect hyperbilirubinemia
Platelet count Before phototherapy After phototherapy P Value*
Summary
Phototherapy is the most widely used therapeutic modality in infants with neonatal jaundice. Phototherapy is very safe and may have no serious long-term effects on neonates; the following adverse effects and complications have been noted: increase insensible water loss, loose stools, retinal damage, hypocalcemia, patent ductus arteriosus (PDA) and skin rash. There are limited studies with different results regarding the effect of conventional count [6,7,8,9]. Some animal and human studies suggest that hyperbilirubinemia and phototherapy may lead to thrombocytopenia [10,13]. Sakha et al study suggests that hyperbilirubinemia and phototherapy may lead to increase the platelet count [7]. According to limited studies with controversial results, the aim of this research was evaluating the hypothesis that conventional phototherapy is able to change platelet count in neonates with indirect hyperbilirubinemia
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