Does controlled ovarian stimulation (COS) in assisted reproductive technologies with recombined human FSH (r-hFSH) need the use of human menopausal gonadotropin (HMG)?

Abstract

Objective: The suppression of the endogenous LH secretion after the use of a high dose of GnRH agonist in the common long luteal protocol and the advent of r-h FSH leads to a debate whether it is necessary to add or not exogenous LH during the COS. This study aims to compare the results of ovarian stimulation using r-h FSH alone versus the combination of r-h FSH and the HMG, in order to determine the threshold of the basal level of LH, after down regulation, that would allow to predict if the COS needs LH supplementation to obtain a correct follicular growth, and an appropriate steroidogenesis.