Abstract
Pre-clinical studies of renal denervation would suggest that the extent of renal nerve injury correlates with outcomes. The “completeness” of renal nerve injury following renal denervation correlates with treatment-based variables such as the depth of ablation, the number of ablations along the length of the artery, and the number of renal arteries successfully ablated. Renal denervation techniques targeting only main renal arteries may lead to suboptimal results in patients with accessory renal artery anatomy. Technological differences among the different systems may make some more suited for this common anatomical variant. The early clinical experience with renal denervation of accessory renal arteries highlights the importance of complete renal denervation for clinical success.
Highlights
Pre-clinical studies of renal denervation would suggest that the extent of renal nerve injury correlates with outcomes
It is unlikely that complete denervation of the entire renal sympathetic nervous system is achieved with any renal artery ablation
Hypertensive patients with accessory renal arteries who undergo renal denervation highlight the issue of whether complete interruption of the renal sympathetic nervous system correlates with changes in blood pressure
Summary
Pre-clinical studies of renal denervation would suggest that the extent of renal nerve injury correlates with outcomes. Renal denervation targets the sympathetic nerves located in the adventitia of the renal artery wall [1]. Hypertensive patients with accessory renal arteries who undergo renal denervation highlight the issue of whether complete interruption of the renal sympathetic nervous system correlates with changes in blood pressure.
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