Abstract
PurposeThe aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model.MethodsSixteen female Wistar Albino rats were included in this study. These animals were divided into two groups: the control group and the clozapine group. The animals in the clozapine group received 10 mg/kg clozapine, and the animals in the control group received tap water by oral gavage daily for 28 days. After sacrification, the femurs of the rats were used for radiologic, histologic, dual-energy X-ray absorptiometry, and biomechanical evaluations.ResultsAlthough the mean values of the clozapine group were higher in terms of histological, bone mineral density, and biomechanical evaluations, the statistical analyses were not significantly different.ConclusionClozapine use did not affect bone density in the rats. Clozapine can be the preferred treatment for patients with schizophrenia to avoid osteoporosis. It will be necessary to conduct further long-term follow-up and controlled studies in animals and humans to confirm these findings.
Highlights
Schizophrenia is a significant psychiatric disorder with a prevalence of 15/100,000 worldwide [1]
Haloperidol primarily inhibits dopaminergic pathways and causes extrapyramidal side effects and postural hypotension [2]. Another important side effect is hyperprolactinemia. To decrease these side effects, new generation antipsychotics are used for schizophrenia treatment
We aimed to investigate the effect of clozapine use on bone tissue by using these four evaluation methods in rats
Summary
Schizophrenia is a significant psychiatric disorder with a prevalence of 15/100,000 worldwide [1]. As it is a chronic mental disorder, long-term medical treatment with antipsychotic drugs is often needed. Routine medical treatment of schizophrenia consists of “typical antipsychotics” such as haloperidol. Haloperidol primarily inhibits dopaminergic pathways and causes extrapyramidal side effects and postural hypotension [2]. To decrease these side effects, new generation antipsychotics are used for schizophrenia treatment.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
