Abstract
Deletion in chemokine receptor CCR5 gene is reported to prevent development of tubal pathology among Dutch Caucasian C. trachomatis infected women. Hence, a pilot study was undertaken, to evaluate the involvement of CCR5 gene in tubal pathology among Indian women with or without Chlamydia infection. Three hundred women with or without Chlamydia infection and with different reproductive manifestations were screened for CCR5 gene using a standardized PCR. Only 6 C. trachomatis infected women without tubal block had heterozygous deletion for this gene. The rest had wild type CCR5 gene, that includes fertile women infected and non infected; infertile women infected and non infected with and without tubal block as well as infected women with history of recurrent spontaneous abortions. The study indicates no role of heterozygous CCR5 D32 gene deletion in prevention of tubal pathology in Chlamydia infected Indian women. Only 2% heterozygous deletion in CCR5 gene is observed in the studied population.
Highlights
Materials and MethodsStudy reported that patients with het- abortion (RSA), infertility, as well as those who Introduction erozygous D 32 deletion had 5 to 10 fold high- had no symptom and sign of any infection (coner bacterial burden than with wild-type gene.[12] trols) but came for family planning advice
Mon cause of pelvic inflammatory disease (PID) and tubal factor infertility (TFI) world wide.[13]
They reported that C. trachomatis exposed women with CCR5 gene D 32 deletion appear to be protected from tubal pathology as well, suggesting a crucial role for CCR5 related specific Th1 and inflammatory responses in the pathogenesis of TFI
Summary
Study reported that patients with het- abortion (RSA), infertility, as well as those who Introduction erozygous D 32 deletion had 5 to 10 fold high- had no symptom and sign of any infection (coner bacterial burden than with wild-type gene.[12] trols) but came for family planning advice. These reports have suggested association of Ethics Committees of the institute as well as of Several studies in different populations CCR5 gene in C. trachomatis infection as well KEM Hospital has approved the study. A extensive periadnexal adhesions and/or distal screening of 100 normal Indian individuals occlusions of one or both tubes as recorded revealed a single (
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