Abstract
Purpose: Treatment development in osteoarthritis continues to focus on chondroprotection, but it is unclear if delaying cartilage loss would reduce joint pain. In published studies, less cartilage in a knee has not been consistently associated with more pain in the knee. Studies have not tested whether cartilage loss over time is associated with worsening pain and have not adjusted for other sources of pain. Further they have not examined whether synovitis or bone marrow lesions, nociceptive tissues, might mediate any effect on pain.
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