Does caffeine intake and coffee consumption associate with endometrial cancer among postmenopausal women in America using NHANES 2003–2012?

Abstract

Background: In 2015, it has been estimated that 54,870 new cases of endometrial cancer will be diagnosed and about 10,170 women will die from it in United States. Previous studies suggested that high levels of coffee consumption may be associated with reduced risk of endometrial cancer among women ages 50–71. Although caffeine is a major ingredient of coffee, one study stated this inverse association does not differ according to caffeine content (regular coffee/decaffeinated coffee). However, the specific measurement of caffeine intake was not clear in that previous study. This study tries to investigate endometrial cancer risk in relation to caffeine intake and coffee consumption.