Does CA-125 have a Role in Early Diagnosis of Ovarian Malignancy in Non-Menopausal Women?

Abstract

Objective: Aim of this study is to assess the role of Cancer Antigen (CA-125) in detection of ovarian malignancy in premenopausal women with ovarian mass. Methods: This observational study was carried out in (blinded). It included 200 women who had preliminary diagnosis of adnexal mass whatever its nature. Adnexal masses were detected either clinically or by ultrasound. Results: The study shows distribution of different pathologies of malignancy, stage of malignancy at diagnosis and benign spectrum in investigated population. The study also reveals CA-125 cutoff point 35.1 and sensitivity and specificity reached 93.1% and 92.2% respectively. Area under the Curve (AUC) was 0.998, Positive Prediction Value (PPV) was 91.7% and Negative Prediction Value (NPV) was 92.1. Conclusion: According to our results CA-125 could be suitable as an ovarian cancer detection marker.