Abstract
COPD and bronchiectasis, chronic inflammation disorders of the bronchial tree through the mechanism of 'spill-over' of inflammatory mediators, may lead to systemic manifestations of illness of the respiratory system and comorbidities. The aim of the study was to evaluate the frequency of coexisting chronic obstructive pulmonary disease and bronchiectasis and influence of bronchiectasis on COPD comorbid diseases. A post-hoc cross-sectional analysis of cohort study of 288 consecutive patients hospitalized due to acute exacerbation of COPD was performed. 177 males (61.5%) and 111 females (38.5%) with mean age = 71.0 8 ± 8.9 yrs, FEV1 % pred. = 34.6 ± 16.8 with COPD diagnosis were studied. In this group, 29 (10.1%) patients presented with bronchiectasis confirmed by HRCT scan. COPD patients with and without bronchiectasis had similar Charlson index results (2.5 vs 2.1, p=0.05). COPD patients with bronchiectasis required longer hospitalization during exacerbation. COPD patients with bronchiectasis significantly more often than patients without this comorbidity revealed the features of colonization with P. aeruginosa (OR = 4.17, p = 0.02). Bronchiectasis is a relatively common comorbidity in COPD patients. COPD patients with bronchiectasis are more frequently colonized with P. aruginosa comparing to non-bronchiectasis COPD patients. We did not confirm the influence of bronchiectasis on COPD comorbidities.
Highlights
Chronic obstructive pulmonary disease (COPD) and bronchiectasis, chronic inflammation disorders of the bronchial tree through the mechanism of ‘spill-over’ of inflammatory mediators, may lead to systemic manifestations of illness of the respiratory system and comorbidities
29 (10.1%) patients presented with bronchiectasis, all confirmed by high-resolution computed tomography (HRCT) scan performed before or during actual hospitalization (Table 1)
No differences relating to obstruction severity in COPD patients with and without bronchiectasis were discovered
Summary
Chronic obstructive pulmonary disease (COPD) and bronchiectasis, chronic inflammation disorders of the bronchial tree through the mechanism of ‘spill-over’ of inflammatory mediators, may lead to systemic manifestations of illness of the respiratory system and comorbidities. = 34.6 ± 16.8 with COPD diagnosis were studied. In this group, 29 (10.1%) patients presented with bronchiectasis confirmed by HRCT scan. Diagnosis of diseases concomitant with COPD is of clinical importance as recognition of comorbidity is a significant predictive factor [4, 5]. Diseases concomitant with COPD should be treated in accordance with current detailed guidelines on particular comorbidities, and diagnosis of COPD should not result in decreased intensity of therapy [2]. Diagnosis of COPD in the patient with heart failure encourages doctors to order more selective beta blockers, whereas the diagnosis of concomitant osteoporosis induces them to use cautiously systemic steroids [6, 7]
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