Abstract
BackgroundObesity is a major global health concern associated with multiple co-morbidities. Bariatric surgery has been considered a good treatment option in cases of morbid obesity. This preliminary study aims to investigate the effect of bariatric surgery on ovarian stimulation characteristics and IVF treatment cycle outcome.MethodsA retrospective study that was performed in a tertiary, university-affiliated medical center and included all patients who underwent IVF treatment both before and after bariatric surgery. Data on ovarian stimulation variables of IVF treatment cycle prior and following the bariatric surgery were reviewed and compared.ResultsFrom January 2005 to June 2014, seven women fulfilled the inclusion criteria. After the operation, BMI was significantly reduced (mean ± SD) (43.1 ± 3.3 vs. 29.6 ± 7.33, p = 0.018), as was the number of gonadotropin ampoules required during stimulation (69.3 ± 10.5 vs. 44.5 ± 17, p = 0.043). No between-cycle differences were observed in peak estradiol level, the number of oocytes retrieved, and percentage of mature oocytes.ConclusionsTo the best of our knowledge, this preliminary case series is the first comparison of IVF cycle characteristics prior to and following bariatric surgery. The operation seems to reduce treatment costs without affecting oocyte or embryo quality. Further large studies are required to establish the surgery’s effect on IVF outcome among infertile women.
Highlights
Obesity is a major global health concern associated with multiple co-morbidities
Prompted by the aforementioned observations, we aimed to investigate the effect of bariatric surgery on ovarian stimulation characteristics and in vitro fertilization (IVF) treatment cycle outcome in infertile patients undergoing IVF treatment, both prior to and following bariatric surgery
Out of 9869 patients treated in our IVF unit during the study period, 18 had a history of bariatric surgery
Summary
Obesity is a major global health concern associated with multiple co-morbidities. Bariatric surgery has been considered a good treatment option in cases of morbid obesity. This preliminary study aims to investigate the effect of bariatric surgery on ovarian stimulation characteristics and IVF treatment cycle outcome. Obesity is a major global health concern with increasing prevalence [1]. Being obese may reduce woman’s fertility, increase risks associated with pregnancy [4], and be detrimental to in vitro fertilization (IVF) outcomes [5,6,7,8]. Treatment options include lifestyle modification, exercise, dietary and pharmacological therapy, liposuction, and bariatric surgery. While non-surgical approaches are generally associated with modest weight loss that is poorly
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