Abstract
Human apolipoprotein E (ApoE) genotype is the only confirmed genetic risk factor for Alzheimer's disease. As the most common isoform, ApoE3 is believed to play a neutral role in AD, while ApoE4 exists in nearly 50% of AD patients. On the other hand ApoE2 is relatively rare and is considered to be a protective variant against AD via its effects on Amyloid beta metabolism. In this retrospective longitudinal study we analyzed a population inside of the AD continuum to investigate the effect of these Epsilon variants on the CSF biomarkers trending levels.
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