Abstract
It is known that acute transient aortic occlusion predispose to lung injury. The aim of this study was to determine whether dexamethasone and tenoxicam could have any protective effect on lung injury in an animal model. Thirty-five white rabbits were randomized into four groups. IR group (n=10), ischemia reperfusion (IR) injury was induced by infrarenal aortic clamping for 3 hours and reperfusion for 2 hour. Dxm group (n=10) was pretreated with 1 mg/kg dexamethasone; Tnx group (n=10) with 10 mg/kg tenoxicam, before clamping. Five animal were in the control group, operated without aortic occlusion. Ischemia reperfusion resulted in a significant increase in lung injury scores (mean 2.6+ in IR group and 2.5+ in Tnx group). The animals pretreated with dexamethasone had significantly lower score (1.7+, p<0.05). Dexamethasone can attenuate the lung injury, but the nonsteroidal antiinflammatory drug, tenoxicam, does not.
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