Does antenatal steroids treatment prior to elective cesarean section at 34-37weeks of gestation reduce neonatal morbidity? Evidence from a case control study.

Abstract

To determine whether antenatal corticosteroids administration prior to an elective cesarean section (ECS) at 34-37weeks gestation is associated with improved neonatal outcome. A case control study of women with singleton pregnancies who underwent ECS between 34 and 37weeks of gestation including two groups: (1) study group in which patients were treated with betamethasone prior to ECS (n=58) and (2) control group matched for gestational age at delivery in which patients did not receive betamethasone (n=107). Neonatal measures including respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), oxygen requirement, admission to the special care unit, hypoglycemia, hyperbilirubinemia and length of hospitalization were determined in both groups. Composite respiratory morbidity was defined as the presence of either RDS, TTN, mechanical ventilation or oxygen requirement. There was no significant difference in the rate of composite respiratory morbidity nor its components between patients with and without betamethasone treatment (25.9 vs. 25.2%, respectively, p=0.9). Antenatal treatment with corticosteroids prior to ECS at 34-37weeks of gestation did not result in significant reduction in neonatal respiratory morbidity in our cohort of patients.