Abstract
Intensive antithrombotic therapies reduce ischaemic complications of percutaneous coronary intervention for ST-segment elevation myocardial infarction, but at a cost of increased bleeding. Bivalirudin consistently reduces haemorrhagic risk, even with potent new oral antiplatelet drugs and contemporary interventional practice. The benefit of bivalirudin must, however, be balanced against increased risk of early subacute stent thrombosis.
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