DOES ALZHEIMER'S DISEASE STEM FROM INSUFFICIENT GLUCOSE CONSUMPTION?

Abstract

Alzheimer's Disease (AD) is a progressively deteriorating disease in which memory, cognition and other cerebral functions deteriorate until death. Glucose is one of the most consumed substances in the world. Lately it's become a trend among doctors to advocate abstaining from glucose because of the hazards of its over-consumption. But in Alzheimer's disease, the situation may be different. This work will show proof of reduced cerebral glucose metabolism being even a hallmark of the disease, perhaps a better predictor of disease progression and severity than amyloid-beta and Tau accumulation. However, AD is prevalent among diabetics. How can we settle this with the glucose hypometabolism in the brain? The answer is simple: For some diabetics, listening to doctor's orders actually leads to a reduction in Glucose consumption. It's possible that a diabetic would avoid all glucose for years, he'll consequently have low blood sugar but this would be considered a success and he would go on avoiding sugar! People who abstain from sugar too intensively are also prone to having hypo-glycemic events which are life threatening events that require hospitalization, because of low sugar, these events are, also, more prevalent among diabetics despite requiring abnormally low, not high, sugar levels. I'll bring results from several studies that show a very strong correlation between the occurrence of low sugar hypoglycemic events in diabetics and an excessive risk of developing AD. I will complete this review by showing of evidence of two studies from the early 90's studying glucose administration to patients and I'll bring their resul