Abstract
<p><strong><strong>There is an erratum to this paper published in <em>Veterinary Evidence</em> Vol 3, Issue 1 (2018): <a id="pub-id::doi" href="/index.php/ve/article/view/168/220" target="_blank">http://dx.doi.org/10.18849/ve.v3i1.168</a></strong></strong></p><p><strong>Clinical bottom line</strong></p><p>There is very weak veterinary clinical and experimental evidence based upon a limited number of studies to indicate that adding transdermal nitroglycerine to other therapies used for management of left-sided congestive heart failure in dogs speeds the resolution of clinical signs.</p><p> </p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />
Highlights
Summary of the evidencePopulation: mixed breed dogs with Seller’s grades 2+ or 3+ mitral regurgitation Sample size: 9 dogs
Placebo and nitroglycerine tape were applied to a clipped area of skin on the chest of healthy beagle dogs
The effect of nitroglycerin tape compared to placebo tape on blood pressure, heart rate and coronary blood flow in healthy beagle dogs
Summary
Population: mixed breed dogs with Seller’s grades 2+ or 3+ mitral regurgitation Sample size: 9 dogs. Five months after production of mitral regurgitation, left atrial dimension and ventricular function were measured using echocardiography/Doppler and left ventricular micromanometry. All dogs were given an IV (saline) and a transdermal placebo (Vaseline). Outcome studied: The effect of 4 different cardioactive drugs on left ventricular function in dogs with mitral regurgitation of 5 months duration. Parameters studied included intracardiac dimension, peak aortic flow, left atrial diastolic and systolic function. Main findings: (relevant to PICO question): When compared to placebo (Vaseline), transdermal nitroglycerin failed to produce an effect on any of the parameters studied
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