Does a patient-specific bladder-filling protocol affect bladder volume and dose in postprostatectomy radiotherapy?

Abstract

Our aim is to develop a patient-specific bladder-filling protocol (PSP) using an ultrasound-based bladder scanner (BS) and compare the volumetric and dosimetric parameters with those of the standard filling protocol (SP) in postprostatectomy patients. Twenty postprostatectomy patients who received salvage radiotherapy (72Gy/36 fx) were included. For PSP, the patient was asked to drink 500mL of water after emptying his bladder. Bladder volume was measured using BS every 10min. Each patient's unique time to reach a 150-200cc volume was used for simulation and treatment. For the SP, the patient was asked about the feeling of having a full bladder. Organs at risk (OAR) were contoured on cone-beam computed tomography (CBCT) scans that were transferred to the treatment planning system (TPS). Treatment plans were applied to CBCTs. Changes in bladder volume and doses for planning computed tomography (PCT) and CBCT were determined. In the SP, there was no significant difference in mean bladder volume for PCT and CBCT (p = 0.139); however, there was a trend for significance in the mean bladder dose (p = 0.074). In PSP, there was no significant difference in the mean bladder volume or dose for PCT and CBCT (p = 0.139 and p = 0.799, respectively). There was a significant difference in terms of mean CBCT bladder volume between the two protocols (p = 0.007), whereas no significant difference was detected in terms of bladder dose (p = 0.130). With PSP, optimal bladder filling was obtained and maintained throughout the whole treatment course, and it was reproducible in every fraction.