Does a cervical pessary reduce the rate of preterm birth in women with a short cervix?

Abstract

To evaluate neonatal outcomes after the use ofa cervical pessary in Japanese women with short cervical length (CL) less than 25mm. This multicenter study involved women with singleton pregnancies between 20 and 29+6 gestational weeks and a CL of less than 25mm. The primary outcome was preterm birth (PTB) before 34weeks of gestation. This study was registered in the Japan Registry of Clinical Trials (JRCT: jRCTs042180102). Two hundred pregnant women were enrolled; 114 in the pessary group and 86 in the expectant management group as controls. In the pessary group, all 114 neonates were investigated for perinatal outcomes, and 112 pregnant women were investigated for primary, and secondary outcomes. In the control group, 86 pregnant women were investigated for primary and secondary outcomes and 86neonates were investigated for neonatal outcomes. There were no significant differences in PTB in≤34,≤37, and≤28weeks of gestation or in preterm rupture of membranes (PROM)≤34weeks between the groups. The gestational weeks at birth and birth weight were significantly higher in the pessary group. Regression analysis demonstrated that the CL decreased without a pessary, whereas the shortening rate was suppressed during the intervention. No significant differences were observed in adverse neonatal outcomes, chorioamnionitis, or preterm PROM. The cervical pessary effectively reduced CLshortening during pregnancy resulting in an average increased gestational age, however, did not reduced the rates of preterm birth.