Does a better vitamin D status help to reduce cardiovascular risks and events?

Abstract

Vitamin D is one and maybe even the most frequently used ‘‘drug’’ in the world as it is recommended as supplement during the early years of life from infancy onwards, and is also recommended systematically for all elderly subjects with little exposure to sunlight. This is mainly inspired by the essential role of the vitamin D endocrine system for bone health [1–3]. The vitamin D receptor and activating enzyme, CYP27B1, are both fairly generally expressed in most tissues and the vitamin D hormone, 1,25(OH)2D, also regulates a great number of genes, far more than needed for calcium transport. Therefore the question and hypothesis arise that the vitamin D endocrine system would have many extra-skeletal effects and that vitamin D supplementation may help to reduce the burden of nearly all major human diseases [1–3]. The cardiovascular system may well be such non classical target tissue for vitamin D action based on a vast and rapidly increasing number of publications and reviews in basic and clinical journals, and even in the lay press. Two manuscripts published in the present issue of endocrine add new data for this debate. Ellis et al. [4] report that cardio respiratory fitness [measured by respiratory quotient (RQ) after moderate exercise and VO2 max during a graded treadmill protocol] of women, aged 60 or more, is inversely correlated with serum 25OHD levels, albeit that this relation was only significant in Afro-Americans and not in Caucasians. The RQ data also suggest that a better vitamin D status was also associated with greater fat oxidation during sub maximal exercise. The study is however handicapped by the low number of subjects and by inconsistency between data in Afro-Americans and Caucasians. Moreover reverse causality is not discussed as it may well be that elderly women with greater habitual exercise have better VO2 max and more exposure to sunlight during exercise. The second study tried to link carotid intima-media thickness (measured by ultrasonography and known to be a good surrogate marker of cardiovascular risks and events) with serum 25OHD and parathyroid hormone levels in a mixed population of vitamin D deficient (mean serum 25OHD of 13 ng/ml) patients recently admitted to a general hospital [5]. Carotid intima-media thickness correlated positively with age and body mass index, as expected, but not with serum 25OHD or parathyroid hormaone levels. There are many possible reasons for this lack of correlation including the low number of subjects with good vitamin D status and the complex mixture of patients. These two studies are in fact a good example of what is presently known with regard to the link between vitamin D status and cardiovascular risks and events. Such a link is plausible as very severe vitamin D deficiency (such as in Cyp27B1 null mice) or resistance (such as in Vdr null mice) is causing renin-mediated hypertension, decreased fibrinolysis and increased thrombogenicity [1–3, 6]. Systemic or cardiomyocyte specific Vdr knock out also causes cardiac hypertrophy and cardiac fibrosis. In vitro studies have also shown many beneficial effects of 1,25(OH)2D on endothelial, smooth muscle or cardiomyocyte function [1– 3]. A large number of observational cross sectional or prospective studies also linked a low vitamin D status with higher cardiovascular risk, events or mortality, especially for subjects with serum 25OHD levels below 25 ng/ml [7, 8]. The link between blood pressure and vitamin D status received great attention with mixed results as PTH was better linked with hypertension than 25OHD status [9]. The R. Bouillon (&) L. Verlinden Clinical and Experimental Endocrinology, KU Leuven and department of Endocrinology, University Hospitals Leuven, Herestraat 49 ON1, box 902, Leuven, Belgium e-mail: roger.bouillon@med.kuleuven.be