Docking Study on T. cruzi Trypanothione Reductase and Iron-Superoxide Dismutase Isoforms of a Series of Imidazole-Based Derivatives as an Approach towards the Design of New Potential Inhibitors

Iván Beltrán-Hortelano,Silvia Galiano,María Font,Silvia Pérez-Silanes

doi:10.3390/proceedings1060651

Iván Beltrán-Hortelano, Silvia Galiano + Show 2 more

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https://doi.org/10.3390/proceedings1060651

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Abstract

Chagas disease (CD) or American trypanosomiasis is a widespread parasitic disease throughout the world. [...]

Highlights

* Correspondence: sperez@unav.es; Tel.: +34-948425600 † Presented at the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain, 8 September 2017
Chagas disease (CD) is caused by the flagellate protozoan parasite Trypanosoma cruzi (T. cruzi), which is mainly transmitted to humans by the faeces of blood-sucking Triatomine insects
There is an urgent necessity to find new compounds that are safer, more effective and more affordable than the existing ones to eradicate T. cruzi, preventing the progression and reducing the risk of transmission of this disease

Summary

Introduction

Docking Study on T. cruzi Trypanothione Reductase and Iron-Superoxide Dismutase Isoforms of a Series of Imidazole-Based Derivatives as an Approach towards the Design of New Potential Inhibitors † Iván Beltrán-Hortelano , 1,2,3 María Font 1,3, Silvia Galiano 1,2 and Silvia Pérez-Silanes 1,2,* Instituto de Salud Tropical (ISTUN), Universidad de Navarra, Campus Universitario, 31008 Pamplona, Spain; ibeltran@alumni.unav.es (I.B.-H.); mfont@unav.es (M.F.); sgaliano@unav.es (S.G.) Sección Síntesis Orgánica, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia y Nutrición, Universidad de Navarra, Campus Universitario, 31008 Pamplona, Spain Sección Modelización Molecular, Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia y Nutrición, Universidad de Navarra, Campus Universitario, 31008 Pamplona, Spain

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