Abstract
IntroductionUrethral stricture, a frequent source of lower urinary tract disorders in men, is still a difficult problem for urologists. Based the anti-restenosis effect of paclitaxel on coronary artery, the role of docetaxel, a semi-synthetic analogue of paclitaxel, in limiting urethral stricture formation was studied.MethodsForty adult New Zealand male rabbits were involved in this study, which were randomly assigned into 3 groups, namely a high dose docetaxel (DH, 0.1 mg/d), a low dose docetaxel (DL, 0.01 mg/d) and a control (C) group, with 16, 16, 8 rabbits in each group, respectively. All animals underwent a 10 mm-long circumferential electrocoagulation of the bulbar urethra with a 13Fr pediatric resectoscope. Drugs were given by urethral irrigation daily and continuous for 28 days. Stricture formation was assessed by retrograde urethrography and videourethroscopy. Urethra pathology was evaluated by hematoxylin and eosin staining and Sirius red staining.ResultsAt the end of this study, 15, 14 and 7 rabbits remained for evaluation in DH, DL and C group, respectively. Urethral diameters in DH, DL and C group were (7.17±1.63) mm, (6.55±0.62) mm, (3.23±1.36) mm, with a normal urethral diameter of (9.08±1.29) mm. Lumen reduction in DH, DL and C group were (36.93±11.58)%, (48.03±7.89)% and (84.66±14.95)%, respectively. Statistically difference could be found between every two groups (p<0.05) both in urethral diameters and in lumen reduction, except for compare of urethral diameters between DH and DL group. Histological examination confirmed mass fibrous tissue and collagen content at the stricture sit in C group, whereas less in docetaxel treated rabbits.ConclusionsDocetaxel could limit urethral stricture formation, which may be due to inhibition of fibrous tissue and collagen expression. Docetaxel may become a new choice in the prevention of urethral stricture formation.
Highlights
Urethral stricture, a frequent source of lower urinary tract disorders in men, is still a difficult problem for urologists
Enlightened by the treatment of organ fibrosis, a few antifibrotic drugs were being used in trial of limiting urethral stricture formation, such as halofuginone, mitomycin C, bitoxin A, somatostatin analogue, glucocorticoid [5,6,7,8,9]
It is widely confirmed that rapamycin and paclitaxel eluting stent showed a satisfactory inhibiting effect on restenosis of coronary artery [10,11]
Summary
A frequent source of lower urinary tract disorders in men, is still a difficult problem for urologists. Based the anti-restenosis effect of paclitaxel on coronary artery, the role of docetaxel, a semi-synthetic analogue of paclitaxel, in limiting urethral stricture formation was studied. Urethral stricture is a frequent source of lower urinary tract disorders in men, characterized by narrowing of the urethra by a noncompliant section of urethral scar tissue. Urethral stricture is commonly treated with urethral dilation and visual internal urethrotomy, which can transiently improve urinary flow. Our previous study had exposed rapamycin could inhibit urethral stricture formation in rabbits [12]. The role of docetaxel, a semi-synthetic analogue of paclitaxel, on inhibition of urethral stricture formation was investigated
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