Dobutamine Stress Test to Evaluate Different Sizes of Prosthetic Aortic Valves

Abstract

Dobutamine stress testing and Doppler echocardiography were used to assess hemodynamics in 27 patients aged 16 to 54 years with various sizes and types of aortic valve prosthesis. All patients underwent a symptom-limited treadmill exercise test within two days of the dobutamine test. There was no significant difference in ejection fractions and transvalvular gradients at rest and during dobutamine stress between St. Jude Medical, Medtronic-Hall, and Carbomedics valves. Exercise duration did not differ significantly among the different types of valve. When patients were classified by their underlying lesion, those with aortic stenosis and those with aortic insufficiency had similar ejection fractions and transvalvular gradients at rest and during dobutamine stress. The mean and peak transvalvular gradients at rest and during dobutamine stress were significantly different in patients with different valve sizes but the extent of the increase in gradients during stress was not significant. Linear regression analysis revealed that both peak and mean gradients during dobutamine stress could be predicted by the resting gradients. There was a negative correlation between valve size and gradients at rest and during stress, while there was a significant correlation between exercise duration and valve size. Dobutamine stress echocardiography was useful for studying hemodynamics in patients with aortic valve prostheses and the findings show that valvular size was the main determinant of exercise capacity.