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Abstract
We have evaluated the effects of intravitreal dobesilate, a synthetic fibroblast growth factor inhibitor, in patients with dry age-related macular degeneration, an inflammatory-related retinal disease without available treatment up to date. 36 eyes from 36 patients with dry age-related macular degeneration were treated with a single intravitreal dobesilate injection. The end points were the improvement from baseline visual acuity and normalization of retinal histology at one month. Intravitreal dobesilate injection resulted in a significant improvement in functional and anatomical outcomes at one month after injection. Our results suggest that intravitreal dobesilate may increase the chance of visual acuity gain in dry age-related macular degeneration, even in cases with initial low vision. This study supports the findings of previously published case reports, regarding the short-term improvement in visual acuity by intravitreal dobesilate injection in different degenerative retinal diseases.
Highlights
Age-related macular degeneration (AMD) is the primary cause of blindness and visual disability in people aged over 50 and its prevalence increases exponentially after the age of 70 [1,2]
We have evaluated the effects of intravitreal dobesilate, a synthetic fibroblast growth factor inhibitor, in patients with dry age-related macular degeneration, an inflammatory-related retinal disease without available treatment up to date. 36 eyes from 36 patients with dry age-related macular degeneration were treated with a single intravitreal dobesilate injection
Our results suggest that intravitreal dobesilate may increase the chance of visual acuity gain in dry age-related macular degeneration, even in cases with initial low vision
Summary
Age-related macular degeneration (AMD) is the primary cause of blindness and visual disability in people aged over 50 and its prevalence increases exponentially after the age of 70 [1,2]. Wet AMD is characterized by choroidal nevoascularization (CNV): the formation of hyperpermeable new blood vessels beneath the retinas that leak plasma and often bleed, leading to the formation of scar tissue which can severely and irreversibly compromise visual acuity. It constitutes only 10% - 15% of all cases, wet AMD accounts for almost 80% of AMD-related blindness [3]. Loss of RPE cells, responsible for the overlying photoreceptors surviving, leads to the gradual degeneration of nearly photoreceptors, resulting in thinning of the retina. RPE degeneration leads to the death of photoreceptor cells causing irreversible vision loss.
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