Doğal ve cerrahi menopoz olgularındaki hormonal değişimin kemik döngüsüne etkisi

Abstract

Objective: In surgical and natural menopause, bone turnover alterations due to estrogen deficiency result in osteoporosis. In the present study, the effect of hormonal alterations on bone turnover markers in women with surgical and natural menopause was planned. Material and Methods: Sixty women with natural menopause and 60 women with surgical menopause applied to menopause clinic of Maltepe Medical Faculty were included study. Serum follicle stimulating hormone (FSH), estradiol (E2), dehydroepiandrosterone sulphate (DHEAS), cortisole, bone-spesific alkaline phosphatase (BAP), paratyroid hormone (PTH), collagen C-telopeptite (CTX) and calcium (Ca) levels were measured. Results: Serum PTH, CTX, E2 and DHEAS levels were higher in women with natural menopause. In women with surgical menopause, serum BAP, cortisole and Ca levels were higher than those with natural menopause. However, these differences were not statistically significant. Serum BAP levels were positively correlated with age, serum cortisole and CTX (r=0.308p=0.004; r=0.301 p=0.023; r=0.302p=0.005; respectively). Serum CTX levels were positively correlated with serum PTH levels (r=0.271 p=0. Oil). While serum PTH levels were positively correlated with age and years since menopause (r=0.381 p=00001; r=0.318p=0.015; respectively), it was negatively correlated with BMI (r=-2.33 p=0.032). Serum DHEAS levels were negatively correlated with age and years since menopause (r=-0.220 p=0.041; r—-0.291 p=0.030; respectively). Conclusion: We concluded that, except estrogen deficiency, there may be various factors for osteoporosis in cases with natural and surgical menopause.