Abstract
Do We Need PK/PD in the Treatment of Urogenital Infections?
Highlights
Urogenital infections are very frequent infections, in the outpatient setting as well as in the health care associated setting and account for a large number of antibiotic administrations in the society
PK/PD assessment in the treatment of infectious diseases is usually addressed by correlating the active serum concentration of an antibiotic (PK) with the pharmacodynamic (PD) in vitro antibacterial activity against a certain pathogen
Urogenital infections comprise a broad spectrum of infectious entities ranging from life threatening systemic diseases such as urosepsis or pyelonephritis, to local infections such as cystitis, to recurrent cystitis, and to prostatitis and epididymo-orchitis, exhibiting specific pharmacological and immunological properties
Summary
Urogenital infections are very frequent infections, in the outpatient setting as well as in the health care associated setting and account for a large number of antibiotic administrations in the society. PK/PD assessment in the treatment of infectious diseases is usually addressed by correlating the active serum concentration of an antibiotic (PK) with the pharmacodynamic (PD) in vitro antibacterial activity against a certain pathogen. This way of looking at the problem does not necessarily reflect the antibacterial activity of a certain antibiotic substance at the site of the infection and its distinct immunological circumstances.
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