Abstract
BackgroundThe aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology.Material and MethodsAn electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently.ResultsA total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias.ConclusionsThe topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density. Key words:Alveolar bone, bone regeneration, topical application, biomaterial, bisphosphonates.
Highlights
Bisphosphonates are a group of drugs commonly used for the treatment of various bone diseases, including osteoporosis, malignant hypercalcemia, multiple myeloma, or Paget’s disease [1,2]
Shibutani et al [24] observed that topical bisphosphonates inhibited the progression of alveolar bone resorption in periimplantitis. The aim of this systemic literature review was to evaluate the potential capacity of the topical application of bisphosphonates to preserve/enhance alveolar bone in oral implantology
Letters to the editor, historic reviews, commentaries, case reports and in vitro studies were excluded. - Search Strategy A literature search was conducted among the PubMed/ Medline (National Library of Medicine, Washington, DC), EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles published from January 2000 up to and including December 2016, using different combinations of the following search terms/key words: “topical bisphosphonates,” “bone preservation,” “bone regeneration,” “bone substitutes,” “bone graft,” “bone defects,” “bone remodeling,” “alveolar bone.”
Summary
Bisphosphonates are a group of drugs commonly used for the treatment of various bone diseases, including osteoporosis, malignant hypercalcemia, multiple myeloma, or Paget’s disease [1,2]. Shibutani et al [24] observed that topical bisphosphonates inhibited the progression of alveolar bone resorption in periimplantitis The aim of this systemic literature review was to evaluate the potential capacity of the topical application of bisphosphonates to preserve/enhance alveolar bone in oral implantology. - Search Strategy A literature search was conducted among the PubMed/ Medline (National Library of Medicine, Washington, DC), EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles published from January 2000 up to and including December 2016, using different combinations (and Boolean Operators: AND, OR, NOT) of the following search terms/key words: “topical bisphosphonates,” “bone preservation,” “bone regeneration,” “bone substitutes,” “bone graft,” “bone defects,” “bone remodeling,” “alveolar bone.”. If the study was lacking two or more of these criteria, it was considered as suffering a high potential risk of bias
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