Abstract
Long terminal repeat retroelements comprise about 8% of the human genome and include the human endogenous retroviruses (HERVs). Earllier it was suspected that HERVs can become active and be involved in the process of transformation of cells, through several oncogenic mechanisms. Abnormal expression of HERVs proteins has been reported for various types of cancer, such as melanoma, breast, prostate, and germ cell cancer, in which encoded transcripts or proteins are overexpressed in the tumor tissues. However, less is known about the association between the HERVs and the colon cancer development. We review the state of the art for colon cancer with respect to the HERVs that can be considered as an open area of investigation, potentially leading to future innovative diagnostic and therapeutic approaches.
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