Do the current house dust mite-driven models really mimic allergic asthma?

Abstract

To the Editors: Animal models play a key role in helping us determine the pathogenesis of diseases, and are vital for the discovery of new therapies and the improvement of existing medication. To do this, the model(s) need to closely mimic the clinical features and, where possible, be relevant to the disease in humans. Classically, the innocuous antigen ovalbumin (OVA) has been used to induce an allergic reaction in animals, and whilst it is possible to reproduce many of the features of the asthmatic lung, i.e. specific immunoglobulin (Ig)E levels, T-helper cell (Th)2-associated eosinophilic inflammation, early and late asthmatic responses (EAR and LAR, respectively), and airway hyperresponsiveness and associated tissue remodelling, researchers began to question the clinical relevance of using OVA as a model allergen 1. In addition, it was commonly felt that the need for systemic delivery of OVA, with an adjuvant such as aluminium hydroxide, did not …