DO PROINFLAMMATORY CYTOKINES SERVE AS DIAGNOSTIC OR PROGNOSTIC INDICATORS FOR TUMOR TYPE, STAGE, SIZE, STANDARDIZED UPTAKE VALUE, AND LYMPHOVASCULAR INVASION IN LUNG CANCER?

Abstract

Objectives: The number of human studies on the association and clinical signicance of alterations in IL-6, sP-Selectin, TNF-α, BNP-32, or procalcitonin (PCT) in lung cancer is small. We aimed to investigate the alterations of proinammatory cytokines and acute-phase reactants in blood and pleural uid and determine their clinical diagnostic or prognostic signicances regarding tumor type, stage, size, standardized uptake value (SUV), and lymphovascular invasion (LVI). Methods: Levels of IL-6, TNF-α, BNP-32, PCT, and sP-selectin were evaluated in blood samples st th st th th obtained preoperatively and postoperatively on 1 , 6 hours and 1 , 4 , and seven days. They also were evaluated in pleural st uid samples obtained postoperatively on 1 hour, and rst and fourth days. These results were analyzed according to the cell type, size, stage, SUV, and LVI of lung cancer. IL-6 values in plasma and pleural uid had Results: various signicant relationships and correlations with histological type, diameter, SUV, stage, and LVI of the tumor. TNF-α values in plasma or pleural uid had signicant relationships with LVI only. PCT values in plasma or pleural uid had signicant relationships with the tumor's diameter, SUV, and LVI. BNP-32 values in plasma or pleural uid had signicant relationships with histological type and SUV of the tumor. sP-Selectin values in plasma or pleural uid had signicant relationships with the stage and SUV of the tumor. We determined various signicant associations and correlations of proinammatory cytokines wi Conclusions: th histological type, size, stage, LVI, and SUV of lung cancer. Studies on this subject would serve to develop diagnostic and prognostic methods in lung cancers.