Abstract
The wide range of cell types produced by single progenitors in the neocortex of mice may result from stochastic rather than deterministic processes.
Highlights
Related research article Llorca A, Ciceri G, Beattie R, Wong FK, Diana G, Serafeimidou-Pouliou E, Fernandez-Otero M, Streicher C, Arnold SJ, Meyer M, Hippenmeyer S, Maravall M, Marin O. 2019
U nderstanding how the many different cell types that make up an adult organism emerge from the successive divisions of a single cell is a central question in biology
Neurons are generated from mother cells called progenitors located below the neocortex: deep-layer neurons are born first, followed by superficial-layer neurons, in an ’inside-out’ pattern during neocortical development
Summary
Related research article Llorca A, Ciceri G, Beattie R, Wong FK, Diana G, Serafeimidou-Pouliou E, Fernandez-Otero M, Streicher C, Arnold SJ, Meyer M, Hippenmeyer S, Maravall M, Marin O. 2019. U nderstanding how the many different cell types that make up an adult organism emerge from the successive divisions of a single cell is a central question in biology. The neocortex contains a large number of different types of nerve cells called neurons, which are organized into six distinct layers.
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