Abstract
Background: Pre-eclampsia and eclampsia is a multisystem disorder affecting approximately 2-7% of all pregnancies and is a significant cause of maternal and fetal morbidity and mortality. Many hemostatic abnormalities have been reported in association with hypertensive disorder of pregnancy. We conducted this prospective case-control study to assess and analyze the platelet parameters in 3rd-trimester normotensives, pre-eclamptic, and eclamptic pregnant women. Materials and methods: This study was conducted in the hematology division of the Department of Pathology, in a rural population-based medical institute over 2 years. In all subjects (cases and controls) 2 ml of blood sample was collected in EDTA vials for platelet counts and platelet indices. The blood samples were run on an automated blood cell counter (Beckman coulter) within 2 hours of collection. The data obtained were tabulated and statistical analyses were performed. Results: The mean platelet count was significantly decreased in cases as compared to controls with increased frequency of thrombocytopenia associated with progression of the disease. Platelet indices, mean platelet volume, and platelet distribution width were increased, whereas the plateletcrit was decreased in cases as compared to the controls. However, the statistically significant difference was found only in platelet distribution width and plateletcrit. Conclusions: We concluded that platelet indices like platelet distribution width and plateletcrit can be useful along with platelet count in early detection of pre-eclampsia and eclampsia instead of relying on platelet count alone.
Highlights
Hypertensive disorders during pregnancy are the second leading cause, after embolism, of maternal mortality in the United States, accounting for almost 15% of such deaths
Do Platelet Indices play a role in assessing the severity of Pre-eclampsia and Eclampsia? Journal of Pathology of Nepal. 2021;11(2): 1790-5
All the blood samples for the cases were obtained from the pregnant women in 3rd trimester of gestation admitted in the obstetric ward and diagnosed as pre-eclamptic or eclamptic patients according to the standard clinical criteria published by the American College of Obstetrics and Gynaecology (2002)[6] whereas randomly selected uncomplicated normotensive pregnant women attending obstetric OPD served as controls
Summary
Hypertensive disorders during pregnancy are the second leading cause, after embolism, of maternal mortality in the United States, accounting for almost 15% of such deaths. Many studies have been done to investigate the changes in platelet indices These changes sometimes appear 4-6 weeks before the significant rise in blood pressure.[5] severe pre-eclampsia, and eclampsia; the severity of preeclampsia was graded into two categories. Many hemostatic abnormalities have been reported in association with hypertensive disorder of pregnancy. We conducted this prospective case-control study to assess and analyze the platelet parameters in 3rd-trimester normotensives, pre-eclamptic, and eclamptic pregnant women
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